Article
SciatiEase With Pregabalin: Drowsiness, Dizziness and the PRECISE Trial
SciatiEase with pregabalin has not been tested as a pair. Pregabalin can cause dizziness and drowsiness, and passionflower in the blend can too. In the PRECISE trial, pregabalin was no better than placebo for sciatica leg pain. That is a reason to talk with your prescriber, not to stop the medicine on your own.
Written by the SciatiEase label deskUpdated · 4 min read
The short version01
Can you take SciatiEase with pregabalin?
SciatiEase with pregabalin is not a tested pairing, and the main overlap is sleepiness. Passionflower, at most 25 mg per 4 capsules, can cause drowsiness, dizziness and confusion (NCCIH, Passionflower).
| Item | Dizziness or drowsiness |
|---|---|
| Pregabalin | More adverse events than placebo, dizziness more common (PRECISE trial, NEJM 2017) |
| Passionflower | Drowsiness, dizziness, confusion |
| Both together | Never studied |
The trial02
What did the PRECISE trial find about pregabalin for sciatica?
The PRECISE trial found pregabalin no better than placebo for sciatica leg pain. It enrolled 209 people for up to 8 weeks (PRECISE trial, NEJM 2017).
Pregabalin 3.7, placebo 3.1. Dizziness was more common with pregabalin.
Your prescription03
Should you stop pregabalin if it is not helping?
Do not stop pregabalin on your own; ask the prescriber about it. Keep taking prescribed medicine until a doctor changes the plan.
- Tell the prescriber about the capsules first.
- Avoid driving until you know how the two sit together.
SciatiEase: from $49 a bottle120 capsules · 1, 3 or 6 bottles · free US shipping on 3 or 6 · 180-day guarantee
See packsThe nerve route04
Where does sciatica pain come from?
Sciatica is a symptom of pressure on the sciatic nerve, which runs from the lower back to the foot. Most cases improve within 4 to 6 weeks (StatPearls, Sciatica).
- Lower backPain may start here or not at all. Many people with sciatica feel more in the leg than in the back.
- Nerve roots, L4 to S3The nerve begins as roots leaving the lower spine. A bulging disc or a narrowed spine at these roots is the usual cause of sciatica.
- ButtockThe nerve passes deep in the buttock. Sitting can make the ache or burning worse.
- Back of the thighPain often shoots down the back of one leg, sometimes like an electric shock.
- KneeAbove the knee the nerve splits into two branches that run down the lower leg.
- Calf and shinNumbness, tingling or pins and needles are common here. Weakness needs a doctor's look.
- FootSymptoms can reach the foot and toes. A foot that drags or slaps when you walk is a reason to get checked soon.
A simplified route, usually on one side only. Sources: MedlinePlus (MedlinePlus, Sciatica) and StatPearls (StatPearls, Sciatica). Pain along the line has many causes; a clinician sorts out which one.
Next step05
What should you read before ordering?
Read the medicines guide and the self-care guide first. 3 bottles cost $177; the guarantee runs 180 days.
FAQ06
SciatiEase with pregabalin questions
Is passionflower safe to take with Lyrica?
Passionflower can cause drowsiness and dizziness, and Lyrica can too, so the two may add up. Ask your prescriber or pharmacist before combining them, and avoid driving until you know.
Did the PRECISE trial mean pregabalin never helps sciatica?
No. It found no average difference from placebo in 209 people. Some individuals may still feel a benefit, so talk with your prescriber rather than judge it from one trial.
How far apart should I take a supplement and pregabalin?
The official site suggests 30 minutes before or after prescription medicine. That is a general tip, so confirm the gap for pregabalin with your pharmacist or prescriber.
Who wrote this07
Written and reviewed by
Pages built from the label, the official site, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by a SciatiEase authorized U.S. retailer, not by the manufacturer. We are paid a commission when you buy through our order links.
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