Official website · SciatiEase authorized U.S. retailer
SciatiEase is a capsule dietary supplement whose bottle reads “Supports Sciatic Nerve Health*”. The label serving is 4 capsules: 500 mg PEA, 250 mg R-alpha lipoic acid, 250 mg acetyl-L-carnitine, 200 mg benfotiamine, four B vitamins and a 50 mg herb blend. The sales page says 2 with breakfast and 2 with dinner. No trial has tested the product itself.
Written by the SciatiEase label desk · Updated
The real bottle, current label: “Supports Sciatic Nerve Health*”. Brand photo.
The sciatic line
A map, not a mechanismA drawing: the capsule riding the line shows a route, not what the ingredients reach or do. No study has tested SciatiEase itself.
PEA dose check
12label stops
| Form | Gelatin capsules, 120 a bottle |
|---|---|
| Serving | 4 capsules, 30 servings |
| Key amounts | PEA 500 mg · R-ALA 250 mg |
| Directions | 2 with breakfast, 2 with dinner |
| Company | SciatiEase Labs, LLC, Smyrna, TN |
| Price | From $49 a bottle |
| Guarantee | 180 days, money back |
What it is01
SciatiEase is a dietary supplement in capsules, sold for sciatic nerve health. One white bottle holds 120 capsules, and the Supplement Facts panel sets a serving at 4 capsules, so a bottle is 30 servings.
The bottle front reads “Supports Sciatic Nerve Health*”, with three smaller lines: “Supports Comfort*”, “Supports Nerve Health*” and “Supports Healthy Inflammatory Response*”. The asterisk points to the standard FDA statement: these claims were not evaluated, and the product is not meant to diagnose, treat, cure or prevent any disease (FDA, Q&A on Dietary Supplements).
The official site names the company as SciatiEase Labs, LLC of Smyrna, Tennessee, and says the capsules are made in Tampa, Florida (SciatiEase official site). Gosciatiease, the site you are reading, is an authorized U.S. retailer. We did not make the product, and we earn money when you order through our links.
Tap any number to see what that part of the bottle says.
The brand name on the blue band. The official site names the company SciatiEase Labs, LLC of Smyrna, Tennessee.
A marketing phrase, not a standard. The real strength is the amounts on the Supplement Facts panel.
A structure/function claim. The asterisk refers to the FDA statement: not evaluated, and not a treatment.
The panel lists 12 lines. Research exists on most single ingredients, rarely at these doses, never on this product.
Supports Comfort*, Supports Nerve Health* and Supports Healthy Inflammatory Response*, each with the asterisk.
120 capsules: 30 days at the 4-capsule label serving, 60 days at 2 a day.
The photo shows the current bottle. The brand's renders show an older front that reads “Maximum Power” and “Sciatic Nerve Formula*”. The panel and the amounts are what count, and they are on the supplement facts page.
Daily routine02
Take 2 capsules with breakfast, and 2 more with dinner to reach the 4-capsule label serving. That is how the sales page puts it, and it lines up with the Supplement Facts panel (SciatiEase sales page).
The official site gives a shorter version: “2 capsules in either the morning or the night” (SciatiEase official site). At 2 a day you get half of every amount on the panel, and a bottle lasts 60 days instead of 30.
The official site also suggests spacing the capsules 30 minutes from prescription medicine. Keep every prescribed dose on its normal schedule.
The sales page starts the day with 2 capsules and a meal. That is half of the 4-capsule serving on the Supplement Facts panel.
Two more with dinner makes the full 4-capsule label serving. The official site instead says 2 a day, morning or night.
The official site suggests taking it 30 minutes before or after prescription medicine. Keep every prescribed dose on schedule.
Note how you sit, walk and sleep. The money-back window is 180 days from the order, so mark the date.
More detail, including what to do if you miss a dose, is on the how to take SciatiEase page.
Ingredients03
SciatiEase lists 12 ingredients: four B vitamins, two nerve nutrients, a two-part “AlphaPalm Blend” and a 50 mg blend of four herbs. Eight of the 12 have a printed amount, which is more than many nerve supplements show.
The biggest amounts per 4 capsules are palmitoylethanolamide (PEA) at 500 mg, R-alpha lipoic acid at 250 mg, acetyl-L-carnitine at 250 mg and benfotiamine at 200 mg. The B vitamins are in their active forms: B2 as riboflavin-5-phosphate, B6 as P5P, folate as methylfolate and B12 as methylcobalamin.
The herbs (feverfew, passionflower, Chinese skullcap and oat straw) share 50 mg with no single amounts. A proprietary blend only has to show its total weight and list its parts from most to least (eCFR, 21 CFR 101.36).
From the Supplement Facts panel. Lines 9-12 are the 50 mg proprietary blend, listed from most to least by weight (eCFR, 21 CFR 101.36). Other ingredients (gelatin capsule, microcrystalline cellulose, vegetable stearate, silica) are not counted.
500 mg500 mg per 4 capsules
A fatty-acid amide the body makes (AlphaPalm Blend)
Evidence: Positive small trials of variable qualityAn illustration made for this site from the label, not a product photo.
500 mg
Studied at300-600 mg a day in a sciatica trial
Watch forFew side effects reported in trials.
Full profile
250 mg250 mg per 4 capsules
R form of alpha-lipoic acid (AlphaPalm Blend)
Evidence: Probably little or no effect on symptoms (Cochrane)An illustration made for this site from the label, not a product photo.
250 mg
Studied at600-1,800 mg a day in diabetic neuropathy trials
Watch forMay lower blood sugar and add to diabetes medicines.
Full profile
250 mg250 mg per 4 capsules
Acetylated form of carnitine
Evidence: Very low certainty; little effect at 1,500 mg or lessAn illustration made for this site from the label, not a product photo.
250 mg
Studied at1,500-3,000 mg a day in neuropathy trials
Watch forStomach upset; a fishy body odor at high doses.
Full profile
200 mg200 mg per 4 capsules
Fat-soluble form of vitamin B1 (thiamin)
Evidence: Small trials, mixed resultsAn illustration made for this site from the label, not a product photo.
200 mg
Studied at300-600 mg a day in the BENDIP trial
Watch forGenerally well tolerated in trials.
Full profile
2 label lines1 mg B12 and 500 mcg DFE folate
Folate, Vitamin B12
Evidence: Helps only if you are lowAn illustration made for this site from the label, not a product photo.
Folate: 500 mcg DFE; Vitamin B12: 1 mg
Studied atDV 400 mcg DFE
Watch forHigh folate can hide a B12 shortage; B12 is in the formula.
Full profile
2 label lines20 mg B6 and 25 mg B2
Vitamin B2, Vitamin B6
Evidence: Not studied for sciaticaAn illustration made for this site from the label, not a product photo.
Vitamin B2: 25 mg; Vitamin B6: 20 mg
Studied at400 mg a day in migraine studies
Watch forHarmless bright yellow urine.
Full profile
2 label lines#1 and #2 of the 50 mg blend
Feverfew, Passionflower
Evidence: Mixed (migraine only)An illustration made for this site from the label, not a product photo.
Feverfew: at most 50 mg; Passionflower: at most 25 mg
Studied atStudied for migraine, not sciatica
Watch forMay slow blood clotting; not for pregnancy; ragweed allergy.
Full profile
2 label lines#3 and #4 of the 50 mg blend
Chinese skullcap, Oat straw
Evidence: Not establishedAn illustration made for this site from the label, not a product photo.
Chinese skullcap: at most 16.7 mg; Oat straw: at most 12.5 mg
Studied atNo studied dose for nerve pain
Watch forRare liver injury reported with skullcap products.
Full profileEvery line, with its % Daily Value and the dose used in research, is in the SciatiEase ingredients guide.
The label04
The panel says a serving is 4 capsules and a bottle holds 30 servings. It then lists every amount per 4 capsules, which matters because the sales page and the official site often talk about 2.
The B vitamins sit far above 100% of the Daily Value: B12 at 41,667% and B2 at 1,923%. Folate is close to normal at 120%. None of that is unusual for a nerve formula, but it does mean the vitamins are a dose, not a top-up.
Tap the numbers on the panel to read each part in plain words.
Tap a number to read that part of the panel.
4 capsules per serving, 30 servings per container: one bottle is 30 days at the label serving.
B vitamins far above 100% DV: B2 1,923%, B6 1,177%, B12 41,667%. Folate is 120%.
B2 25 mg, B6 20 mg, folate 500 mcg DFE, B12 1 mg, all in active forms.
R-alpha lipoic acid 250 mg plus palmitoylethanolamide (PEA) 500 mg, both amounts printed.
250 mg per 4 capsules. Neuropathy trials used 1,000-3,000 mg a day.
200 mg per 4 capsules, a fat-soluble form of vitamin B1.
Feverfew, passionflower, Chinese skullcap and oat straw, each a 4:1 extract. Single amounts are not shown.
Gelatin capsule, microcrystalline cellulose, vegetable stearate and silica. Gelatin means not vegetarian.
The official site's comparison chart lists PEA 600 mg, R-ALA 300 mg and ALCAR 300 mg. The panel says 500, 250 and 250. We follow the panel.
Dose vs research05
PEA is in the range used in a sciatica trial; the other headline ingredients are below the doses most studies used. The bars compare 2 capsules, the full 4-capsule serving and the daily amounts in published research.
In the largest PEA study in sciatica, 636 adults took 300 or 600 mg a day for 3 weeks, and pain scores fell more than with placebo (Keppel Hesselink, J Pain Res 2015). Four SciatiEase capsules hold 500 mg; two hold 250 mg.
Alpha-lipoic acid, acetyl-L-carnitine and benfotiamine were studied mainly in diabetic nerve damage, at higher doses, with small or uncertain results (Cochrane, Alpha-lipoic acid 2024) (Cochrane, Acetyl-L-carnitine 2019) (BENDIP trial, benfotiamine 2008).
| Ingredient | Evidence | What it found |
|---|---|---|
| PEA | Meta-analysis, 10 trials (Artukoglu et al., Pain Physician 2017) | Lower pain scores than controls; few trials of variable quality |
| PEA in sciatica | 636-person trial (Keppel Hesselink, J Pain Res 2015) | 600 mg a day beat 300 mg and placebo over 3 weeks |
| Alpha-lipoic acid | Cochrane, 816 adults (Cochrane, Alpha-lipoic acid 2024) | Probably little or no effect on neuropathy symptoms at 6 months |
| Acetyl-L-carnitine | Cochrane, 907 people (Cochrane, Acetyl-L-carnitine 2019) | Very low certainty; little difference at 1,500 mg a day or less |
| Benfotiamine | BENDIP trial, 165 people (BENDIP trial, benfotiamine 2008) | Mixed: one symptom score improved in one analysis only |
| B vitamins | Cochrane, 741 people (Cochrane, Vitamin B for neuropathy) | Not enough evidence to say they help or harm neuropathy |
Claims vs evidence06
Nobody knows yet, because no study has tested SciatiEase. What exists are studies of single ingredients, mostly PEA, at doses that only partly match the label.
The sales page goes much further. It says the formula “awakens the damaged and dead cells” of the sciatic nerve and that the nerve is “Dying of Starvation” (SciatiEase sales page). Neither line comes with a source, and neither matches how sciatica usually starts: with pressure on a nerve root from a disc or a narrowed spine (MedlinePlus, Sciatica).
Each sales claim sits next to the evidence below.
Claims as printed on the sales page (SciatiEase sales page) and the bottle. Health claims need competent and reliable scientific evidence, generally human trials (FTC, Health Products Compliance).
Do not stop or cut a prescribed pain or nerve medicine because you started a supplement. Talk to the doctor who prescribed it first, and tell your pharmacist about every supplement you take (FDA, Mixing Medications and Supplements).
Bottle claims07
They are structure/function claims, the kind supplements may make with the FDA asterisk. They describe support for normal body function, not treatment of a disease.
The FDA does not approve supplements or their claims before sale; the company is responsible for making them truthful (FDA, Q&A on Dietary Supplements). Here is each one next to what the research on the ingredients shows.
The bottle says“Supports Sciatic Nerve Health*”
What the evidence saysThe product itself has never been tested in a trial. PEA has small sciatica trials at doses above or near the label amount; B vitamins help nerves mainly when you are low in them. (Keppel Hesselink, J Pain Res 2015) (Cochrane, Vitamin B for neuropathy)
The bottle says“Supports Comfort*”
What the evidence saysA meta-analysis of PEA found lower pain scores in small, mixed-quality trials. Feverfew was studied for migraine, not leg pain. (Artukoglu et al., Pain Physician 2017) (NCCIH, Feverfew)
The bottle says“Supports Nerve Health*”
What the evidence saysAlpha-lipoic acid, acetyl-L-carnitine and benfotiamine were studied in diabetic neuropathy, mostly at higher doses, with small or uncertain effects. (Cochrane, Alpha-lipoic acid 2024) (Cochrane, Acetyl-L-carnitine 2019) (BENDIP trial, benfotiamine 2008)
The bottle says“Supports Healthy Inflammatory Response*”
What the evidence saysPEA and alpha-lipoic acid act on inflammation in lab work. No human study shows this blend changes inflammation around the sciatic nerve. (Artukoglu et al., Pain Physician 2017) (MSKCC, Alpha-lipoic acid)
Claims as printed on the photographed bottle front. The asterisk points to the FDA statement: these statements have not been evaluated, and the product is not intended to diagnose, treat, cure, or prevent any disease (FDA, Q&A on Dietary Supplements).
Safety08
Most adults tolerate these ingredients, but five groups should check with a doctor first. Answer the questions below; a yes means a talk with your doctor or pharmacist before the first capsule.
The ingredient to watch is vitamin B6. Four capsules hold 20 mg. That is well under the U.S. upper limit of 100 mg a day, but above the 12 mg limit Europe set in 2023, and nerve symptoms from long-term B6 have been reported at lower doses than once thought (NIH ODS, Vitamin B6) (TGA, Vitamin B6 rescheduling).
Feverfew may slow blood clotting (NCCIH, Feverfew), passionflower can cause drowsiness (NCCIH, Passionflower), and skullcap products have been linked to rare liver injury (LiverTox, Skullcap). If tingling or numbness gets worse while you take it, stop and call your doctor. More on side effects and interactions.
Know the line09
Sciatica is pain, numbness or tingling along the sciatic nerve, from the lower back down one leg. It is a symptom, most often caused by a herniated disc, spinal stenosis or a tight muscle in the buttock pressing on the nerve (MedlinePlus, Sciatica).
Most cases get better within 4 to 6 weeks, even without treatment (StatPearls, Sciatica). The American College of Physicians puts heat, staying active and nondrug care first for new back pain (ACP guideline, Annals 2017).
Some signs are an emergency. Know them before you try anything else.
A simplified route, usually on one side only. Sources: MedlinePlus (MedlinePlus, Sciatica) and StatPearls (StatPearls, Sciatica). Pain along the line has many causes; a clinician sorts out which one.
See a doctorLeg pain that lasts more than a few weeks, keeps you from sleeping or working, or keeps coming back deserves an exam. A supplement should not delay it.
Go nowLoss of bladder or bowel control or numbness between the legs can mean cauda equina syndrome, an emergency. Call 911 or go to an emergency room.
Red flags from StatPearls and MedlinePlus (StatPearls, Cauda Equina Syndrome) (AANS, Cauda Equina Syndrome) (MedlinePlus, Sciatica).
Read sciatica basics and sciatica self-care.
Verdict10
The strengths are a readable label and a long guarantee; the weak spots are untested claims and a dose that depends on taking 4 capsules. Here is the short list.
Our view: a label with real amounts and one ingredient, PEA, that has sciatica data behind it. Treat it as a supplement alongside care, never as a substitute for a diagnosis.
Prices11
SciatiEase costs $69 for 1 bottle plus $6.95 shipping, $177 for 3 bottles and $294 for 6, on the official site. The 3 and 6-bottle packs ship free in the US.
Per bottle that is $69, $59 or $49. At the 4-capsule label serving a bottle lasts 30 days, so the 6-pack works out to about $1.63 a day.
Try it
$69total
$69 + $6.95 shipping = $75.95
$6.95 US shipping
Free US shipping
$177total
$59 a bottle
Free US shipping
Lowest per bottle
$294total
$49 a bottle
Free US shipping
Prices on the official SciatiEase site, October 18, 2026 (SciatiEase official site). One bottle adds $6.95 shipping and handling; 3 and 6 bottles ship free in the US. Per-day figures leave out shipping and use 30 days a bottle at the 4-capsule label serving and 60 at 2 capsules. We never show the struck "regular" prices; the checkout shows the final total.
You need 3 bottles. Lowest total: 1 x 3-bottle for $177, with free US shipping.
Uses the official-site prices: $69 for 1 bottle plus $6.95 shipping, $177 for 3 and $294 for 6. Bottle icons fill one per bottle. Use it to plan only; the final total appears at checkout.
Order buttons go to the SciatiEase order page, where these prices and the guarantee apply (SciatiEase official site). We never show the struck “regular” prices. See where to buy SciatiEase.
Guarantee12
You have 180 days from your order to ask for your money back. Call +1 (844) 361-1273 or use the support form with your order ID, then mail the bottles back with tracking.
One FAQ on the official site also mentions a year and refunds minus shipping and handling, so confirm the terms on your order (SciatiEase official site).
Your order ID is what the desk needs. The 180 days count from the order.
One bottle at the label serving runs out around day 30. Keep your prescribed medicine and physical therapy going the whole time.
Call +1 (844) 361-1273 or use the support form on sciatiease.com with your order ID.
Send the bottles to the returns address with your full name, email and order ID. Return postage is on you.
Once the bottles are credited, the refund posts in 3-5 business days and reaches your card 5-10 days later. Return shipping is on you. Read the guarantee and the refund policy.
Reviews13
We publish a review only after it is matched to a real order and the buyer agrees, and none is verified yet. The cards below carry the photos the vendor supplied, with every other detail left blank until then.
The seller's sample copy includes a score, counts and named reviewers. We leave them out, because the FTC bans fake and unrepresentative reviews (FTC, Fake Reviews Final Rule 2024).
4.5out of 5
Based on 514 verified ratings
Filled in only from reviews matched to a real order. How we check reviews.
I do laundry for the house. That's the cue. Two with eggs. Car seat on the way to the store is the scorecard, not a lab. I keep it by the hymnals. Reordered when two days were left.
Pack review 1, as supplied · Photo supplied by the vendor
I sit in bleachers a lot. 180-day window. I marked the calendar, not an app. I keep it by the bus keys. I take it when I hang the apron.
Pack review 2, as supplied · Photo supplied by the vendor
I watch grandkids twice a week. Two at dinner only if I remember. I don't chase four if breakfast already happened. I keep it in the ferry bag. I take it before the first call.
Pack review 3, as supplied · Photo supplied by the vendor
See how we check SciatiEase reviews and our answer to is SciatiEase legit?
Photos and badges14
They show the real bottle and how orders ship, not results. Every image below comes from the brand, and each caption says what it is.
The one badge, a 180-day money-back seal, matches the guarantee. The other marks on the bottle, such as “Maximum Strength”, are words, not certificates.
Photos and renders supplied by the brand. They show the product; they do not show results. (SciatiEase official site)
The renders show an older label front ('Maximum Power', 'Sciatic Nerve Formula*'). The photographed bottles carry the current front. (SciatiEase official site)
Lot SE-26/GO-2829 is a seller reference, not lab proof. How to check a bottle is on the batch verify page, and who runs this site is on about us.
FAQ15
No question matches. Try another word.
SciatiEase is a capsule dietary supplement sold for sciatic nerve health. A serving is 4 capsules with PEA, R-alpha lipoic acid, acetyl-L-carnitine, benfotiamine, four B vitamins and a 50 mg herb blend; a bottle holds 120 capsules.
No study has tested SciatiEase, so nobody can say. Its main ingredient, PEA, lowered sciatica pain scores at 300-600 mg a day in one large trial (Keppel Hesselink, J Pain Res 2015), and four capsules hold 500 mg. Other ingredients show small or uncertain effects.
The Supplement Facts panel lists a serving of 4 capsules. The sales page says 2 with breakfast and 2 more with dinner; the official site says 2 a day. Follow the bottle you receive and do not exceed the label serving.
Ask your doctor or pharmacist first. Gabapentin can make you drowsy (MedlinePlus, Gabapentin), and passionflower in the herb blend can add drowsiness (NCCIH, Passionflower). Keep taking gabapentin exactly as prescribed.
No. The FDA does not approve dietary supplements before they are sold, and the bottle's claims carry the FDA asterisk saying they were not evaluated (FDA, Q&A on Dietary Supplements). The official site says it is made in Tampa, Florida.
Online, yes: Walmart.com has a listing sold by the brand's own seller account, and Amazon and eBay show listings from sellers we could not verify. It is not in stores. Our order buttons go to the official order page, where the 180-day guarantee applies.
On the official site: 1 bottle $69 plus $6.95 shipping, 3 bottles $177 ($59 each) and 6 bottles $294 ($49 each), with free US shipping on 3 and 6. That is about $1.63 to $2.30 a day at 4 capsules.
The SciatiEase label desk writes them. No medical reviewer is named yet; the box at the foot of each page marks where those details will go once a review is on file.
More on the SciatiEase FAQ page and in our guides.
SciatiEase authorized U.S. retailer
Start with a check of your medicines, then pick a pack. Three or six bottles ship free in the US and cost less per bottle, and the 180-day guarantee covers your order.
