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SciatiEase Research: What Studies Exist for Each Ingredient?

Quick answer

SciatiEase research is ingredient research: we found no published trial of the finished capsules. PEA has the closest match, a 636-person sciatica trial. Alpha-lipoic acid and acetyl-L-carnitine were studied in diabetic neuropathy, mostly at higher doses than the label holds.

Written by the SciatiEase label deskUpdated · 4 min read

The SciatiEase Supplement Facts panel listing 12 label lines
The Supplement Facts panel, the starting point for any ingredient search.

The studies01

What SciatiEase research exists?

SciatiEase research exists only for single ingredients, never for the finished capsule.

Best evidence by ingredient
IngredientStudyFinding
PEA636 adults with sciatica, 3 weeksPain fell more at 600 mg than placebo (Keppel Hesselink, J Pain Res 2015)
Alpha-lipoic acidCochrane, 816 adultsProbably little or no effect on symptoms (Cochrane, Alpha-lipoic acid 2024)
Acetyl-L-carnitineCochrane, 907 peopleVery low certainty; little at 1,500 mg or less (Cochrane, Acetyl-L-carnitine 2019)

Dose gap02

Do the label amounts match the studies?

Only PEA lands inside its studied range, at 500 mg per 4 capsules. The sciatica trial used 300 or 600 mg a day.

At 2 capsules a day, PEA halves to 250 mg.

  • PEA

    167% of the low end at 4 capsules
    2 capsules (sales-page morning dose)250 mg
    4 capsules (label serving)500 mg
    300-600 mg a day in a sciatica trial300-600 mg

    Printed on the panel: 500 mg per 4 capsules. (Keppel Hesselink, J Pain Res 2015)

  • R-alpha lipoic acid

    42% of the low end at 4 capsules
    2 capsules (sales-page morning dose)125 mg
    4 capsules (label serving)250 mg
    600-1,800 mg a day in neuropathy trials600-1,800 mg

    Printed on the panel: 250 mg per 4 capsules. (Cochrane, Alpha-lipoic acid 2024)

  • Acetyl-L-carnitine

    17% of the low end at 4 capsules
    2 capsules (sales-page morning dose)125 mg
    4 capsules (label serving)250 mg
    1,500-3,000 mg a day in neuropathy trials1,500-3,000 mg

    Printed on the panel: 250 mg per 4 capsules. (Cochrane, Acetyl-L-carnitine 2019)

  • Benfotiamine

    67% of the low end at 4 capsules
    2 capsules (sales-page morning dose)100 mg
    4 capsules (label serving)200 mg
    300-600 mg a day in neuropathy trials300-600 mg

    Printed on the panel: 200 mg per 4 capsules. (BENDIP trial, benfotiamine 2008)

Coral bars: what 2 or 4 capsules hold, from the Supplement Facts panel. Green bars: daily amounts of that ingredient alone in studies; the light extension shows a range. Studies tested single ingredients, mostly in diabetic neuropathy or back pain, not SciatiEase.

The gaps03

What does the research not tell you?

The research does not tell you whether this blend works, or whether the herbs add anything. The herbs sit in a 50 mg blend with hidden amounts.

The trial used micronized PEA, and the label does not say which form it holds. See the benefits page.

Ask first

Keep taking prescribed medicine.

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Ordering04

What does a bottle cost if you want to try it?

A bottle costs $69 plus $6.95 shipping, and 3 bottles cost $177.

3 bottles$177$59 a bottle · free US shippingBest value6 bottles$294$49 a bottle · free US shipping

FAQ05

Questions about the evidence

Is there a clinical trial of the SciatiEase formula?

We found none. The sales page cites no study of the capsules, and the official site, checked October 18, 2026, shows no trial of the finished product either.

Why do ingredient studies not prove a combined capsule works?

Mixing nutrients changes doses, forms and timing. A result for one ingredient at one dose may not carry over to a blend, so only a trial of the product can answer.

Where can I read the PEA sciatica study myself?

Search the first author, Guida, 2010, on PubMed. Bring it to a doctor if you want a second opinion on what it means for you.

Who wrote this06

Written and reviewed by

Written byThe SciatiEase label deskGosciatiease, SciatiEase authorized U.S. retailer

Pages built from the label, the official site, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.

Medically reviewed byDr. Julia Buchfuhrer, MD, PhysicianRole: Medical reviewerReview date: October 19, 2026

Last updated . Read our editorial standards and how we check reviews. This website is run by a SciatiEase authorized U.S. retailer, not by the manufacturer. We are paid a commission when you buy through our order links.

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