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What Is a PEA Nerve Pain Supplement, and What Do Studies Say About It?
A PEA nerve pain supplement is a capsule built around palmitoylethanolamide, a fat-like molecule the body makes itself. Trials found lower pain scores than placebo, though quality varies. SciatiEase holds 500 mg of PEA per 4 capsules and 250 mg per 2. No trial has tested the SciatiEase product itself.
Written by the SciatiEase label deskUpdated · 4 min read
The basics01
What is a PEA nerve pain supplement?
A PEA nerve pain supplement is a capsule that supplies palmitoylethanolamide, a fat-like molecule your body already makes. The FDA does not approve supplements (FDA, Q&A on Dietary Supplements).
| Full name | Palmitoylethanolamide |
|---|---|
| In SciatiEase | 500 mg per 4 capsules, 250 mg per 2 |
The evidence02
Does PEA help with nerve pain in studies?
In several trials, PEA users reported lower pain scores than placebo users, but quality varies. A pooled review of ten trials noted weak side-effect tracking (Artukoglu et al., Pain Physician 2017).
The best sciatica data is 636 adults taking 600 mg for 3 weeks: pain fell from 7.1 to 2.1 out of 10, against 6.6 to 4.6 on placebo (Keppel Hesselink, J Pain Res 2015).
No trial used this product.
The label03
How much PEA is in SciatiEase?
SciatiEase holds 500 mg of PEA per 4 capsules, inside the 300-600 mg range from the sciatica trial. At 2 capsules you get 250 mg, under the trial's low dose.
Tap a number to read that part of the panel.
- Serving size
4 capsules per serving, 30 servings per container: one bottle is 30 days at the label serving.
- % Daily Value
B vitamins far above 100% DV: B2 1,923%, B6 1,177%, B12 41,667%. Folate is 120%.
- Four B vitamins
B2 25 mg, B6 20 mg, folate 500 mcg DFE, B12 1 mg, all in active forms.
- AlphaPalm Blend 750 mg
R-alpha lipoic acid 250 mg plus palmitoylethanolamide (PEA) 500 mg, both amounts printed.
- Acetyl-L-carnitine
250 mg per 4 capsules. Neuropathy trials used 1,000-3,000 mg a day.
- Benfotiamine
200 mg per 4 capsules, a fat-soluble form of vitamin B1.
- Proprietary blend 50 mg
Feverfew, passionflower, Chinese skullcap and oat straw, each a 4:1 extract. Single amounts are not shown.
- Other ingredients
Gelatin capsule, microcrystalline cellulose, vegetable stearate and silica. Gelatin means not vegetarian.
SciatiEase: from $49 a bottle120 capsules · 1, 3 or 6 bottles · free US shipping on 3 or 6 · 180-day guarantee
See packsBefore you order04
Who should ask a clinician before taking PEA?
Anyone on prescribed medicine, pregnant or nursing should ask a clinician first. Keep taking prescribed medicine. The warning panel is not in the images we have; follow the bottle you receive.
Leg pain past 4 weeks needs a doctor (MedlinePlus, Sciatica). Details are in the ingredients guide and on the supplement facts page.
Three bottles cost $177, six cost $294, with a 180-day guarantee.
FAQ05
PEA questions, answered
Is PEA found in food?
Small amounts occur in foods such as egg yolk, but capsule doses are far larger than food provides, so food is not a practical way to match research amounts.
Is a PEA supplement a painkiller?
No. It is sold as a dietary supplement, not a painkiller, and its pain research is mixed in quality. Keep taking prescribed pain medicine unless your doctor changes it.
How long did people take PEA in the sciatica trial?
The 636-adult sciatica trial lasted 3 weeks. Longer-term results for this formula are not published, so ask a clinician.
Who wrote this06
Written and reviewed by
Pages built from the label, the official site, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by a SciatiEase authorized U.S. retailer, not by the manufacturer. We are paid a commission when you buy through our order links.
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