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Do nerve pain supplements that work include PEA?

Quick answer

Nerve pain supplements that work are led, on the evidence, by PEA. A sciatica trial of 636 adults found lower pain at 600 mg a day than placebo. Alpha-lipoic acid and acetyl-L-carnitine have weaker results. No trial tested a retail capsule as a whole.

Written by the SciatiEase label deskUpdated October 18, 2026 · 4 min read

Illustrated station sign for PEA on a transit line — An illustration made for this site.

PEA01

What did trials find for PEA in nerve pain supplements that work?

Nerve pain supplements that work best on paper contain PEA, with one sciatica trial as the main support. It enrolled 636 adults at 300 or 600 mg a day for 3 weeks (Keppel Hesselink, J Pain Res 2015).

Pain fell from 7.1 to 2.1 on 600 mg, against 6.6 to 4.6 on placebo. A pooled review of 10 trials also found lower pain scores, with variable quality (Artukoglu et al., Pain Physician 2017).

The trial used micronized PEA. Most labels do not say which form they hold.

Sciatica trial, 3 weeks
Group	Pain before	Pain after
600 mg PEA	7.1	2.1
Placebo	6.6	4.6

The rest02

Do alpha-lipoic acid and carnitine help nerve pain?

Alpha-lipoic acid and carnitine have weaker support for nerve pain than PEA.

The 2024 Cochrane review of alpha-lipoic acid found probably little or no effect on symptoms at 6 months (Cochrane, Alpha-lipoic acid 2024). The ALCAR review rated its certainty very low (Cochrane, Acetyl-L-carnitine 2019).

A lower score is a feeling, not repaired nerves. Keep taking prescribed medicine.

Doses03

How do label doses compare with studied doses?

Label doses of PEA can match studies, while other nutrients often fall short. The bars below use the SciatiEase label at 4 and 2 capsules.

PEA
167% of the low end at 4 capsules

2 capsules (sales-page morning dose)250 mg
4 capsules (label serving)500 mg
300-600 mg a day in a sciatica trial300-600 mg
Printed on the panel: 500 mg per 4 capsules. (Keppel Hesselink, J Pain Res 2015)
R-alpha lipoic acid
42% of the low end at 4 capsules

2 capsules (sales-page morning dose)125 mg
4 capsules (label serving)250 mg
600-1,800 mg a day in neuropathy trials600-1,800 mg
Printed on the panel: 250 mg per 4 capsules. (Cochrane, Alpha-lipoic acid 2024)
Acetyl-L-carnitine
17% of the low end at 4 capsules

2 capsules (sales-page morning dose)125 mg
4 capsules (label serving)250 mg
1,500-3,000 mg a day in neuropathy trials1,500-3,000 mg
Printed on the panel: 250 mg per 4 capsules. (Cochrane, Acetyl-L-carnitine 2019)
Benfotiamine
67% of the low end at 4 capsules

2 capsules (sales-page morning dose)100 mg
4 capsules (label serving)200 mg
300-600 mg a day in neuropathy trials300-600 mg
Printed on the panel: 200 mg per 4 capsules. (BENDIP trial, benfotiamine 2008)

Coral bars: what 2 or 4 capsules hold, from the Supplement Facts panel. Green bars: daily amounts of that ingredient alone in studies; the light extension shows a range. Studies tested single ingredients, mostly in diabetic neuropathy or back pain, not SciatiEase.

SciatiEase: from $49 a bottle120 capsules · 1, 3 or 6 bottles · free US shipping on 3 or 6 · 180-day guarantee

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One label04

Where can you see a PEA capsule label?

The SciatiEase order page lists 500 mg of PEA per 4 capsules. That is a label fact, not a result.

Three bottles are $177 and six are $294, with a 180-day guarantee.

See the PEA page and the supplement facts page.

3 bottles$177$59 a bottle · free US shipping

Best value6 bottles$294$49 a bottle · free US shipping

FAQ05

Questions about PEA and others

What is micronized PEA and does it matter?

Micronized PEA is ground into very small particles, and the sciatica trial used it. Labels rarely say which form they hold, so a matching milligram count may not mean matching results.

Is PEA an approved nerve pain medicine?

No. In the US it is sold as a dietary supplement, and the FDA does not approve supplements (FDA, Q&A on Dietary Supplements). Prescription options exist, so ask your doctor what suits your condition.

Why did the PEA trial run only 3 weeks?

Short trials are common in pain research. Three weeks says little about months of use or safety over time, which is one reason to treat results with care.

Who wrote this06

Written and reviewed by

Written byThe SciatiEase label deskGosciatiease, SciatiEase authorized U.S. retailer

Pages built from the label, the official site, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.

Medically reviewed byDr. Julia Buchfuhrer, MD, PhysicianRole: Medical reviewerReview date: October 19, 2026

Last updated October 18, 2026. Read our editorial standards and how we check reviews. This website is run by a SciatiEase authorized U.S. retailer, not by the manufacturer. We are paid a commission when you buy through our order links.

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