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Nerve Pain Supplements Ingredients: What Each One Is and the Evidence

Quick answer

Nerve pain supplements ingredients usually fall into four groups: B vitamins, antioxidant and energy nutrients such as alpha-lipoic acid and acetyl-L-carnitine, PEA, and herb extracts. Each has a different evidence level, and the dose on the label often differs from the dose used in studies.

Written by the SciatiEase label deskUpdated October 18, 2026 · 4 min read

Station-sign illustration for the PEA ingredient page — An illustration made for this site: PEA, the ingredient with the most sciatica trial data.

The short answer01

What are the common nerve pain supplements ingredients?

Nerve pain supplements ingredients are mostly B vitamins, alpha-lipoic acid, acetyl-L-carnitine, PEA and a few herbs.

Benfotiamine is vitamin B1 in a fat-soluble form. In the BENDIP trial, 300 and 600 mg a day gave mixed results.

Common ingredients and what studies found
Ingredient	What it is	Evidence in brief
B vitamins	Essential nutrients	Insufficient evidence for neuropathy (Cochrane, Vitamin B for neuropathy)
Alpha-lipoic acid	Antioxidant	Probably little effect at 6 months (Cochrane, Alpha-lipoic acid 2024)
Acetyl-L-carnitine	Amino acid form	Very low certainty
PEA	Fatty acid compound	Lower pain scores in trials (Artukoglu et al., Pain Physician 2017)
Herb extracts	Plant extracts	Mostly migraine or other uses

Dose check02

Do the amounts in nerve pain supplements match studies?

The amounts in nerve pain supplements often sit below the daily doses used in studies.

Alpha-lipoic acid trials used 600 to 1,800 mg a day, and acetyl-L-carnitine trials 1,500 to 3,000 mg. The bars compare a typical label with those amounts.

PEA
167% of the low end at 4 capsules

2 capsules (sales-page morning dose)250 mg
4 capsules (label serving)500 mg
300-600 mg a day in a sciatica trial300-600 mg
Printed on the panel: 500 mg per 4 capsules. (Keppel Hesselink, J Pain Res 2015)
R-alpha lipoic acid
42% of the low end at 4 capsules

2 capsules (sales-page morning dose)125 mg
4 capsules (label serving)250 mg
600-1,800 mg a day in neuropathy trials600-1,800 mg
Printed on the panel: 250 mg per 4 capsules. (Cochrane, Alpha-lipoic acid 2024)
Acetyl-L-carnitine
17% of the low end at 4 capsules

2 capsules (sales-page morning dose)125 mg
4 capsules (label serving)250 mg
1,500-3,000 mg a day in neuropathy trials1,500-3,000 mg
Printed on the panel: 250 mg per 4 capsules. (Cochrane, Acetyl-L-carnitine 2019)
Benfotiamine
67% of the low end at 4 capsules

2 capsules (sales-page morning dose)100 mg
4 capsules (label serving)200 mg
300-600 mg a day in neuropathy trials300-600 mg
Printed on the panel: 200 mg per 4 capsules. (BENDIP trial, benfotiamine 2008)

Coral bars: what 2 or 4 capsules hold, from the Supplement Facts panel. Green bars: daily amounts of that ingredient alone in studies; the light extension shows a range. Studies tested single ingredients, mostly in diabetic neuropathy or back pain, not SciatiEase.

Plant extracts03

Which herbs show up in nerve pain formulas?

The herbs in nerve pain formulas are often feverfew, passionflower, skullcap and oat straw.

Passionflower can cause drowsiness (NCCIH, Passionflower). Keep taking prescribed medicine, and ask a pharmacist before mixing herbs with sedatives or blood thinners.

Herb amounts inside a blend are not shown.
Pregnancy is a common reason to skip them.

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One example04

Which of these ingredients does SciatiEase use?

SciatiEase uses all four groups: four B vitamins, R-ALA, ALCAR, benfotiamine, PEA and four herbs. The ingredients page has each line.

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FAQ05

Questions about nerve pain supplement ingredients

Is benfotiamine the same as thiamine?

Benfotiamine is a fat-soluble relative of thiamine, or vitamin B1, and the body converts it. Studies on nerves used it at 300 to 600 mg a day, with mixed results.

What is R-alpha lipoic acid?

R-ALA is one mirror-image form of alpha-lipoic acid, the form the body makes. Most trials tested regular alpha-lipoic acid, so ask what form a label uses.

Are nerve supplement ingredients safe together?

Often, but combined amounts count. B6 from several products can add up, and alpha-lipoic acid may lower blood sugar, so ask your pharmacist to check the whole list.

Who wrote this06

Written and reviewed by

Written byThe SciatiEase label deskGosciatiease, SciatiEase authorized U.S. retailer

Pages built from the label, the official site, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.

Medically reviewed byDr. Julia Buchfuhrer, MD, PhysicianRole: Medical reviewerReview date: October 19, 2026

Last updated October 18, 2026. Read our editorial standards and how we check reviews. This website is run by a SciatiEase authorized U.S. retailer, not by the manufacturer. We are paid a commission when you buy through our order links.

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