Article
Methylcobalamin vs Cyanocobalamin: Which B12 Form, and Does It Matter for Numbness?
Methylcobalamin vs cyanocobalamin compares two forms of vitamin B12, and the research reviewed here found no evidence that absorption differs by form. SciatiEase uses methylcobalamin at 1 mg per 4 capsules. Numbness and tingling can come from low B12, so a blood test is the first step.
Written by the SciatiEase label deskUpdated · 4 min read
The two forms01
What is methylcobalamin vs cyanocobalamin?
Methylcobalamin vs cyanocobalamin is a choice between two B12 forms. Methylcobalamin is one of the two active forms. Cyanocobalamin is a man-made form the body must convert first.
Reviewers found no evidence that absorption differs by supplement form (NIH ODS, Vitamin B12).
| Methylcobalamin | Cyanocobalamin | |
|---|---|---|
| Type | Active form | Synthetic |
| In SciatiEase | Yes, 1 mg | Not listed |
The route02
Can low B12 cause numbness?
Low B12 can cause numbness and tingling in the hands and feet, even without anemia. The daily need is only 2.4 mcg, and no upper limit was set (NIH ODS, Vitamin B12).
- Lower backPain may start here or not at all. Many people with sciatica feel more in the leg than in the back.
- Nerve roots, L4 to S3The nerve begins as roots leaving the lower spine. A bulging disc or a narrowed spine at these roots is the usual cause of sciatica.
- ButtockThe nerve passes deep in the buttock. Sitting can make the ache or burning worse.
- Back of the thighPain often shoots down the back of one leg, sometimes like an electric shock.
- KneeAbove the knee the nerve splits into two branches that run down the lower leg.
- Calf and shinNumbness, tingling or pins and needles are common here. Weakness needs a doctor's look.
- FootSymptoms can reach the foot and toes. A foot that drags or slaps when you walk is a reason to get checked soon.
A simplified route, usually on one side only. Sources: MedlinePlus (MedlinePlus, Sciatica) and StatPearls (StatPearls, Sciatica). Pain along the line has many causes; a clinician sorts out which one.
Who runs low03
Which medicines can lower B12?
Metformin can lower B12, and so can acid reducers such as proton pump inhibitors and H2 blockers. A doctor can order a blood test (NIH ODS, Vitamin B12).
- Keep taking prescribed medicine
- Ask before adding a supplement
SciatiEase: from $49 a bottle120 capsules · 1, 3 or 6 bottles · free US shipping on 3 or 6 · 180-day guarantee
See packsThe label04
How much B12 is in SciatiEase?
SciatiEase has 1 mg of methylcobalamin per 4 capsules, or 500 mcg per 2. That is 41,667% of the Daily Value at 4 capsules.
Three bottles cost $177, six cost $294, with a 180-day guarantee. See the ingredients guide and who it fits.
FAQ05
B12 form questions
Is methylcobalamin better than cyanocobalamin for neuropathy?
No study we read shows that. Reviewers found no evidence that absorption differs by form, so a doctor's blood test matters more than the form on the label.
How many micrograms is 1 mg of B12?
One milligram equals 1,000 micrograms. The adult daily need is 2.4 mcg, so 1 mg is far above it, though no upper limit was set for B12.
Should I get a B12 blood test before taking a supplement?
If you have numbness or tingling, yes, ask a doctor first. Treating it with a supplement alone could delay finding the cause.
Who wrote this06
Written and reviewed by
Pages built from the label, the official site, the sales page and linked NIH, FDA, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by a SciatiEase authorized U.S. retailer, not by the manufacturer. We are paid a commission when you buy through our order links.
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